Your Treatment Journey and Support with ASAP | YORVIPATH® (palopegteriparatide) Patient Site

Your Treatment Journey and Support With A·S·A·P

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Pay as little as $5 per month for your YORVIPATH prescription*

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Preparing for your treatment journey

Starting a new treatment can feel overwhelming, but knowing what to expect along your treatment journey, and who to turn to for support, can help prepare you.

With YORVIPATH, you may work with the Ascendis Signature Access Program® (A·S·A·P) and a specialty pharmacy along the way. Both are able to support you along your journey.

Select where you currently are in your treatment journey for more information on what support may be provided to you:

I am considering taking YORVIPATH, or my doctor has prescribed YORVIPATH directly through a specialty pharmacy

I am enrolled in A·S·A·P

What to know if you are considering taking YORVIPATH

All patients will receive YORVIPATH from a specialty pharmacy

YORVIPATH is a specialty medication that is shipped directly to your door by one of these specialty pharmacies, Orsini Specialty Pharmacy or PANTHERx Rare Pharmacy.

Orsini Specialty Pharmacy

Phone: (888) 204-7802

Fax: (877) 471-8175

orsinispecialtypharmacy.com

PANTHERx Rare Pharmacy

Phone: (888) 379-1821

Fax: (877) 914-0604

pantherxrare.com

You may receive an unknown phone call from one of the specialty pharmacies above. It is important to answer the call to confirm shipping details and avoid delays.

All patients can receive support from their specialty pharmacy, but enrollment in A·S·A·P grants you additional support, including a dedicated Nurse Advocate and financial assistance, if eligible. Read more about support with A·S·A·P below, and if you have already been prescribed YORVIPATH, you can ask your specialty pharmacy to help you enroll.

What to expect at each step of your treatment journey with A·S·A·P

Starting a new treatment can feel overwhelming, but you don’t have to navigate it alone. Your Nurse Advocate and Patient Access Liaison (PAL) are here to assist you.

Have questions? The A·S·A·P team is just one call away. Call 1-844-442-7236 (8 AM to 8 PM ET, Monday through Friday).

Overview of A·S·A·P support along your treatment journey

Enrollment
Insurance approval
process
Refills and ongoing
support
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A·S·A·P will call you from 1-844-442-7236; be sure to answer and save this number.
Navigating insurance can be overwhelming. A·S·A·P can help with benefits investigations and guiding you through the process to approval.
A·S·A·P will check in and can help you navigate any changes in insurance coverage.
A·S·A·P also will send you a Welcome Kit that includes a travel case for YORVIPATH!
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If you have questions about YORVIPATH and want to speak with someone to learn more, call 1-844-442-7236 (8 AM to 8 PM, Monday through Friday) and follow the prompts to reach A·S·A·P.

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Connect with a PAL

Get individualized support and education about YORVIPATH through a Patient Access Liaison (PAL). Sign up to get connected.

Financial Support

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Co-Pay Program

Pay as little as $5 per month for your YORVIPATH prescription*
Eligible patients with commercial health insurance may pay as little as $5 per month for YORVIPATH
*Eligibility required. Federal and state healthcare beneficiaries are ineligible (participants in programs such as Medicaid, Medicare, Medigap, VA, DOD, or TRICARE). Offer not valid for cash-paying patients. Terms and conditions apply. For full terms and conditions and eligibility criteria, click here.

If you do not have insurance or are underinsured, you may qualify for treatment at $0 through the Ascendis Patient Assistance Program (PAP).†

†For full terms and conditions and eligibility criteria, click here.
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Important Safety Information and use

What is the most important information I should know about YORVIPATH?

YORVIPATH may cause serious side effects, including:

  • Allergic (hypersensivity) reactions, including anaphylaxis. Stop taking YORVIPATH and get medical help right away if you have any of the following symptoms of an allergic reaction: swelling of your face, lips, mouth or tongue, breathing problems, fainting, dizziness, feeling lightheaded (low blood pressure), fast heartbeat, itching, rash or hives.
  • High levels of calcium in the blood (hypercalcemia). YORVIPATH can cause some people to have higher blood calcium levels than normal. Your healthcare provider should check your blood calcium before you start and during your treatment with YORVIPATH. Tell your healthcare provider right away if you have nausea, vomiting, dizziness, feeling thirsty, confusion, muscle weakness, or irregular heartbeat. Hypercalcemia is more likely to occur within the first 3 months of starting YORVIPATH, but it may occur at any time.

INDICATION AND LIMITATIONS OF USE

What is YORVIPATH® used for?

YORVIPATH is a prescription medicine used to treat adults with low parathyroid hormone (PTH) (hypoparathyroidism).

It is not known if YORVIPATH is safe and effective in people who have been recently diagnosed with hypoparathyroidism after surgery; if it is started in people with low levels of blood calcium; or in children. Do not use YORVIPATH in children and young adults whose bones are still growing.

  • Low levels of calcium in the blood (hypocalcemia). People who stop using, miss, or change a dose of YORVIPATH may have an increased risk of low blood calcium levels, but hypocalcemia may occur at any time. Tell your healthcare provider right away if you have tingling in your fingertips, toes, lips or tongue, muscle spasms or cramps, oral numbness, depression, have problems thinking or remembering, abnormal heart rhythms, or seizures.
  • Possible bone cancer (osteosarcoma). Tell your healthcare provider right away if you have pain in any areas of your body that does not go away or any new or unusual lumps or swelling under your skin that is tender to touch. These are some of the signs and symptoms of osteosarcoma and your healthcare provider may need to do further tests.

Who should not take YORVIPATH?

Do not use YORVIPATH if you have had a severe allergic reaction to palopegteriparatide or any of the other ingredients in YORVIPATH.

What should I tell my healthcare provider before taking YORVIPATH?

Before using YORVIPATH, tell your healthcare provider about all of your medical conditions, including if you:

  • are at higher risk of a type of bone cancer called osteosarcoma. This is especially important:
    • if you have a bone disease that increases your risk of developing osteosarcoma (including if you have Paget’s disease).
    • if a blood test shows that you have unexplained increases in bone alkaline phosphatase.
    • if you have cancer of the bones or other cancer that has spread to your bones.
    • if you are having or have had radiation therapy to the skeleton.
    • if you are affected with a condition that runs in your family that can increase your chance of getting cancer in your bones.
  • take medicines that contain digoxin, are used to treat osteoporosis, or can affect calcium levels in your blood.
  • are pregnant or plan to become pregnant. It is not known if YORVIPATH will harm your unborn baby. Tell your healthcare provider if you become pregnant during treatment with YORVIPATH.
  • are breastfeeding or plan to breastfeed. It is not known if YORVIPATH passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with YORVIPATH.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. YORVIPATH and other medicines may affect each other causing side effects.

What are the possible side effects of YORVIPATH?

YORVIPATH may cause serious side effects:

  • Decrease in blood pressure when you change positions (orthostatic hypotension). Some people may feel dizzy, get a fast heartbeat, or feel light-headed right after injecting YORVIPATH. For the first few doses, give your injection of YORVIPATH in a place where you can sit or lie down right away if you get these symptoms. If your symptoms get worse or do not go away, contact your healthcare provider before you continue using YORVIPATH.
  • Digoxin toxicity if you are using digoxin and YORVIPATH at the same time. Tell your healthcare provider if you experience irregular heart rhythm, heart palpitations, confusion, loss of appetite, nausea, vomiting, diarrhea, or vision problems.

The most common side effects of YORVIPATH include injection site reactions, vasodilatory signs or symptoms such as a drop in blood pressure or lightheadedness when standing up, headache, diarrhea, back pain, high calcium levels, and sore throat.

These are not all of the possible side effects of YORVIPATH. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. You may also report side effects to Ascendis Pharma at 1-844-442-7236.

Please see the full Prescribing Information for YORVIPATH and the Medication Guide.

INDICATION AND LIMITATIONS OF USE

close isi icon open isi icon

What is YORVIPATH® used for?

YORVIPATH is a prescription medicine used to treat adults with low parathyroid hormone (PTH) (hypoparathyroidism).

It is not known if YORVIPATH is safe and effective in people who have been recently diagnosed with hypoparathyroidism after surgery; if it is started in people with low levels of blood calcium; or in children. Do not use YORVIPATH in children and young adults whose bones are still growing.

Important Safety Information and use

close isi icon open isi icon

What is the most important information I should know about YORVIPATH?

YORVIPATH may cause serious side effects, including:

  • Allergic (hypersensivity) reactions, including anaphylaxis. Stop taking YORVIPATH and get medical help right away if you have any of the following symptoms of an allergic reaction: swelling of your face, lips, mouth or tongue, breathing problems, fainting, dizziness, feeling lightheaded (low blood pressure), fast heartbeat, itching, rash or hives.
  • High levels of calcium in the blood (hypercalcemia). YORVIPATH can cause some people to have higher blood calcium levels than normal. Your healthcare provider should check your blood calcium before you start and during your treatment with YORVIPATH. Tell your healthcare provider right away if you have nausea, vomiting, dizziness, feeling thirsty, confusion, muscle weakness, or irregular heartbeat. Hypercalcemia is more likely to occur within the first 3 months of starting YORVIPATH, but it may occur at any time.
  • Low levels of calcium in the blood (hypocalcemia). People who stop using, miss, or change a dose of YORVIPATH may have an increased risk of low blood calcium levels, but hypocalcemia may occur at any time. Tell your healthcare provider right away if you have tingling in your fingertips, toes, lips or tongue, muscle spasms or cramps, oral numbness, depression, have problems thinking or remembering, abnormal heart rhythms, or seizures.
  • Possible bone cancer (osteosarcoma). Tell your healthcare provider right away if you have pain in any areas of your body that does not go away or any new or unusual lumps or swelling under your skin that is tender to touch. These are some of the signs and symptoms of osteosarcoma and your healthcare provider may need to do further tests.

Who should not take YORVIPATH?

Do not use YORVIPATH if you have had a severe allergic reaction to palopegteriparatide or any of the other ingredients in YORVIPATH.

What should I tell my healthcare provider before taking YORVIPATH?

Before using YORVIPATH, tell your healthcare provider about all of your medical conditions, including if you:

  • are at higher risk of a type of bone cancer called osteosarcoma. This is especially important:
    • if you have a bone disease that increases your risk of developing osteosarcoma (including if you have Paget’s disease).
    • if a blood test shows that you have unexplained increases in bone alkaline phosphatase.
    • if you have cancer of the bones or other cancer that has spread to your bones.
    • if you are having or have had radiation therapy to the skeleton.
    • if you are affected with a condition that runs in your family that can increase your chance of getting cancer in your bones.
  • take medicines that contain digoxin, are used to treat osteoporosis, or can affect calcium levels in your blood.
  • are pregnant or plan to become pregnant. It is not known if YORVIPATH will harm your unborn baby. Tell your healthcare provider if you become pregnant during treatment with YORVIPATH.
  • are breastfeeding or plan to breastfeed. It is not known if YORVIPATH passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with YORVIPATH.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. YORVIPATH and other medicines may affect each other causing side effects.

What are the possible side effects of YORVIPATH?

YORVIPATH may cause serious side effects:

  • Decrease in blood pressure when you change positions (orthostatic hypotension). Some people may feel dizzy, get a fast heartbeat, or feel light-headed right after injecting YORVIPATH. For the first few doses, give your injection of YORVIPATH in a place where you can sit or lie down right away if you get these symptoms. If your symptoms get worse or do not go away, contact your healthcare provider before you continue using YORVIPATH.
  • Digoxin toxicity if you are using digoxin and YORVIPATH at the same time. Tell your healthcare provider if you experience irregular heart rhythm, heart palpitations, confusion, loss of appetite, nausea, vomiting, diarrhea, or vision problems.

The most common side effects of YORVIPATH include injection site reactions, vasodilatory signs or symptoms such as a drop in blood pressure or lightheadedness when standing up, headache, diarrhea, back pain, high calcium levels, and sore throat.

These are not all of the possible side effects of YORVIPATH. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. You may also report side effects to Ascendis Pharma at 1-844-442-7236.

Please see the full Prescribing Information for YORVIPATH and the Medication Guide.

Hypopara = hypoparathyroidism; DOD = Department of Defense; VA = Veterans Affairs.

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